A few favorites:
"There's a Martian war machine outside. They'd like to have a word with you about the common cold."
"Love? What has love got to do with marriage?"
Londo: "I hate my life"
G'Kar: "So do I."
"The universe is driven by the complex interaction between three ingredients: matter, energy, and enlightened self-interest."
"The doc says his chances are 50/50. Either way, I'd stay on this side of the glass if I were you."
"Now, I go to spread happiness to the rest of the station. It is a terrible responsibility but I have learned to live with it."
"I know, I know. It's a Russian thing. When we're about to do something stupid, we like to catalog the full extent of our stupidity for future reference."
Sinclair: Ready?
Delenn: Why do you always ask that when you are about to do something massively unwise?
Sinclair: Tradition.
"All I can say is that enthusiasm, sincerity, genuine compassion, and humor can carry you through any .. lack of .. prior experience with .. high numerical value."
Refa: Why would I abandon them? (meaning the Shadows)
Londo: Because I have asked you. And because your loyalty to our people should be greater than your ambition. And because I have poisoned your drink.
And, to steal from LH's sig, "Vir! Intelliegence has nothing to do with politics!"
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Regards,
Joe